![]() ![]() When you have high cholesterol, it means there’s too much low-density lipoprotein (LDL) cholesterol (the “bad” cholesterol) in your blood. RELATED: Statins: Uses, common brands, and safety info How do statins work? Read on to learn more about how statins work, their interaction with grapefruit, and what you can do to avoid problems. If you’re taking a statin to help lower your cholesterol levels, it’s important to understand the potential grapefruit interaction. This causes an increase in the levels of statins in the blood, which can increase the risk of side effects, most notably muscle problems. Grapefruit contains a chemical called furanocoumarin, which inhibits the enzyme that breaks down statins. While effective, one potential downside to statin drugs is their ability to interact with grapefruit. Statins are some of the most prescribed drugs in the United States, and they’re generally considered safe and effective. They work by inhibiting the enzyme in the liver responsible for making cholesterol, known as HMG-CoA reductase. Statins are a class of drugs used to lower cholesterol levels. How do statins work? | What happens if you eat grapefruit while on statins? | Which statins are safe with grapefruit? | Can I eat grapefruit in the morning and take Lipitor at night? | Other grapefruit-drug interactions They’ll also monitor you for muscle-related side effects.Share on Facebook Facebook Logo Share on Twitter Twitter Logo Share on LinkedIn LinkedIn Logo Copy URL to clipboard Share Icon URL copied to clipboard This may be especially important if you have kidney or liver problems. If you need colchicine and a statin or fibrate, your healthcare provider may start you at lower doses of either medication. This is an off-label use of colchicine since it’s not FDA approved for this reason. In fact, statins and colchicine may be prescribed together to prevent heart problems. Keep in mind that possible colchicine interactions like this one don’t occur in everyone. If you think you’re experiencing symptoms of rhabdomyolysis, seek immediate medical attention. The risk is higher if you’re older or have existing kidney or liver problems. You should also watch for signs of kidney injury, like dark red or brown urine. This may cause trouble moving your arms and legs. Common signs of rhabdomyolysis include muscle pain and weakness. It can lead to kidney failure and even death. Rhabdomyolysis is a rare but serious medical condition caused by the breakdown of muscle tissue. ![]() And, the risk of a more serious side effect - rhabdomyolysis - can also occur. So when they’re combined, this risk is higher. Fibrates include fenofibrate (Tricor) and gemfibrozil (Lopid).Ĭolchicine, statins, and fibrates each have muscle aches and pain as a side effect. These include simvastatin (Zocor, FloLipid), atorvastatin (Lipitor), and lovastatin.įibrates are another group of medications that treat high cholesterol (and high triglycerides). Some statins are more likely to interact with colchicine than others. Statins are a group of medications that treat high cholesterol. Your healthcare provider and pharmacist can use it to check for colchicine interactions. ![]() Before starting colchicine, create an updated list of your medications. But this isn’t a complete list of possible interactions. Most colchicine interactions raise your risk of side effects like muscle pain.īelow, we discuss seven of the most important colchicine interactions to know. Like most medications, colchicine can have drug interactions. It’s also approved to treat an autoimmune condition called familial Mediterranean fever. It works by blocking multiple inflammatory processes that occur during gout attacks. It gets harder to treat the longer you wait.Ĭolchicine (Colcrys, Mitigare) is a medication that’s used to prevent and treat gout attacks. If you experience a gout attack, you’ll want to start medication right away. During a gout attack, you may experience pain and swelling in a specific joint. Gout occurs when a substance called uric acid builds up in the joints. If you have gout, you know how painful a gout attack can be.
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